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Jill M. Goldstein, PhD

Founder & Director

Dr. Jill M. Goldstein is a Professor of Psychiatry and Medicine at Harvard Medical School, and Executive Director of the Innovation Center on Sex Differences in Medicine (ICON), a collaborative effort between Massachusetts General Hospital (Departments of Psychiatry, Obstetrics and Gynecology, Neurology, and Medicine-Cardiology) and the Harvard T.H. Chan School of Public Health, partnering with the Women’s Heart Alliance, and WomenAgainstAlzheimers.

Her program of research, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain consists of an interdisciplinary team of investigators, integrating structural and functional brain imaging studies, psychophysiology, neuroendocrine studies of hormones and brain function, genetics, immune biomarkers, and collaborative efforts with basic neuroscientists studying genes, hormones, markers of immune function, and the brain.  Brain circuitries under investigation include the stress response and mood circuitries, memory/working memory (including aging of memory circuitry), and reward circuitry implicated in the neural circuitry of obesity and metabolic disturbance. Sex differences in disorders of interest include major depressive disorder and its comorbidity with cardiometabolic diseases, psychoses, and aging and risk for Alzheimer's disease. This work has been funded by the National Institutes of Health for about 30 years. She has published >170 articles, chapters and other original and peer-reviewed work in these areas.

Dr. Goldstein is also an administrative and educational leader in women’s health and sex differences in medicine, locally, nationally and globally. She has served on several scientific review boards and participated in strategic planning for the National Institute of Mental Health, NIH Office of Research on Women’s Health, and the Institute of Medicine. Finally, Dr. Goldstein is a leader in training the next generation of women and men in women’s health and sex differences in medicine.

Recently, she launched an Innovation Center on Sex Differences in Medicine (ICON). The center crosses disciplines, departments, and institutions to tackle a major public health challenge of our time, the comorbidity of depression, cardiovascular disease and Alzheimer's disease, by applying a sex differences lens to develop sex-dependent heart-brain therapeutics for precision medicine.

Selected Publications

Makris N, Swaab DF, van der Kouwe A, Abbs B, Boriel D, Handa R, Tobet S, Goldstein JM. Volumetric Parcellation Methodology of the Human Hypothalamus in Neuroimaging: Normative Data and Sex Differences. NeuroImage. 2013 April 1 (69):1-10. PMCID: PMC3575213

Goldstein, JM, Langer, A., Lesser, J. Sex Differences in disorders of the heart and brain: A global crisis of multimorbidity and novel opportunity, JAMA Psychiatry Viewpoint, 2020. PMID: 32639554

Konishi K., Cherkerzian S., Aroner S., Jacobs EG., Rentz, D., Remington A., Aizley, H., Hornig M., Klibanski A., Goldstein JM. Impact of BDNF and sex on maintaining intact memory function in early midlife. Neurobiology of Aging. 2019 doi.org/10.1016/j.neurobiolaging.2019.12.014. PMID: 31948671

Garcia RG, Mareckova K, Holsen LM, Whitfield-Gabrieli S, Napadow V, Barbieri R, Goldstein JM. Impact of sex and depressed mood on the central regulation of cardiac autonomic function. Neuropsychopharmacology. 2020; 45(8): 1280-1288. doi: 10.1038/s41386-020-0651-x. PMID: 32152473. PMCID: PMC7298013

Goldstein JM, Cohen JE, Mareckova K, Holsen L, Whitfield-Gabrieli S, Gilman SE, Buka SL, Hornig, M. Impact of prenatal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. 2021; In press, Proceedings of the National Academy of Sciences.