The Clinical Neuroscience Laboratory
FOR SEX DIFFERENCES IN THE BRAIN
Director: Jill M. Goldstein, PhD
The Clinical Neuroscience Laboratory of Sex Differences in the Brain integrates scientists from clinical and basic neuroscience perspectives to address questions of why men and women are at different risks for psychiatric disorders and their comorbidity with general medical disorders, such as cardiovascular disease (CVD). The work of the lab takes a lifespan approach to their investigations targeting naturalistic windows of opportunity for the study of sex differences when the brain and body are differentially flooded or depleted of gonadal hormones, e.g., fetal development and puberty, and, for female-specific periods, pregnancy and the menopausal transition compared to age-matched men. The work in the lab is particularly focused on the roles of steroid hormones, genes, and markers of immune function in understanding sex effects in major depression, psychoses, memory decline with aging and comorbidity of these with cardiometabolic disorders. We believe that an understanding of these hormonal, genetic, and immune pathways will provide knowledge for the development of sex-dependent or sex-specific therapeutics.
Women, Heart and Brain Global Initiative
The CNL sits in the broader context of this recently launched initiative, a collaborative effort between Massachusetts General Hospital and Harvard T.H. Chan School of Public Health, partnering with the Women's Heart Alliance and WomenAgainstAlzheimer's