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Jill M. Goldstein, PhD

Founder & Director

Dr. Jill M. Goldstein is a Professor of Psychiatry and Medicine at Harvard Medical School, and Executive Director of the Women, Heart and Brain Global Initiative, a collaborative effort between Massachusetts General Hospital (Departments of Psychiatry, Obstetrics and Gynecology, Neurology, and Medicine-Cardiology) and the Harvard T.H. Chan School of Public Health, partnering with the Women’s Heart Alliance, and WomenAgainstAlzheimers. She is also a Senior Scientist at Brigham and Women’s Hospital in the Department of Medicine, Division of Women’s Health.

Her program of research, called the Clinical Neuroscience Laboratory of Sex Differences in the Brain consists of an interdisciplinary team of investigators, integrating structural and functional brain imaging studies, psychophysiology, neuroendocrine studies of hormones and brain function, genetics, immune biomarkers, and collaborative efforts with basic neuroscientists studying genes, hormones, markers of immune function, and the brain.  Brain circuitries under investigation include the stress response and mood circuitries, memory/working memory (including aging of memory circuitry), and reward circuitry implicated in the neural circuitry of obesity and metabolic disturbance. Sex differences in disorders of interest include major depressive disorder and its comorbidity with cardiometabolic diseases, psychoses, and aging and risk for Alzheimer's disease. This work has been funded by the National Institutes of Health for about 30 years. She has published >170 articles, chapters and other original and peer-reviewed work in these areas.

Dr. Goldstein is also an administrative and educational leader in women’s health and sex differences in medicine, locally, nationally and globally. She has served on several scientific review boards and participated in strategic planning for the National Institute of Mental Health, NIH Office of Research on Women’s Health, and the Institute of Medicine. Finally, Dr. Goldstein is a leader in training the next generation of women and men in women’s health and sex differences in medicine.

Recently, she launched a new initiative called Women, Heart and Brain Global Initiative (whnbi.mgh.harvard.edu), a collaborative effort between MGH and Harvard T.H. Chan School of Public Health, partnering with the Women's Heart Alliance and WomenAgainstAlzheimer's. The initiative crosses disciplines, departments, and institutions to tackle a major public health challenge of our time, [the comorbidity of depression, cardiovascular disease and Alzheimer's disease] by applying a sex differences lens to develop sex-dependent heart-brain therapeutics for precision medicine.

Selected Publications

Goldstein, JM, Seidman, LJ, Horton, NJ, Makris, M, Kennedy, DN, Caviness, VS, Faraone, SV, Tsuang, MT. Normal sexual dimorphism of the adult human brain assessed by in-vivo magnetic resonance imaging. Cerebral Cortex, 2001, 11:490-497. (Also, awarded the cover page from this work.) PMID: 11375910

Goldstein, JM, Seidman, LJ, O’Brien, L, Horton, N, Kennedy, DN, Makris, N, Caviness, VS, Faraone, SV, Tsuang, MT. Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Archives of General Psychiatry, 2002; 59:154-164. PMID: 11825137

Goldstein, JM, Jerram, M, Poldrack, R, Kennedy, DN, Seidman, LJ, Makris, N. Hormonal cycle modulates arousal circuitry in women using fMRI.  Journal of Neuroscience, 2005;25:9309-9316. PMID: 16207891

Goldstein, JM.  Sex, hormones, and affective arousal dysfunction in schizophrenia.  Hormones and Behavior, 2006; 50; 612-622. PMID: 16876167

Goldstein, JM, Seidman, JL, Makris N, Ahern, T. O’Brien, LM, Caviness, VS, Kennedy, DN, Faraone, SV, Tsuang, MT.  Hypothalamic abnormalities in schizophrenia: Sex effects & genetic vulnerability, Biological Psychiatry, 2007: 61: 935-945; Awarded the cover page image. PMID: 17046727

Goldstein, JM, Buka, SL, Seidman, LJ, Tsuang, MT.  Specificity of familial transmission of schizophrenia psychosis spectrum and affective psychoses in the New England Family Studies high risk design. Archives of General Psychiatry 2010; 67:458-467. PMCID: PMC3049996

Goldstein, JM, Jerram, M, Abbs, B, Whitfield-Gabrieli, S, Makris, N.  Sex differences in stress response circuitry activation dependent on female hormonal cycle. Journal of Neuroscience 2010, 30 (2): 431-438. PMCID: PMC2827936

Holsen, LM, Spaeth, SB, Lee, J-H, Ogden, LA, Klibanski, A, Whitfield-Gabrieli, S, Goldstein, JM. Stress response circuitry hypoactivation related to hormonal dysfunction in women with major depression. Journal of Affective Disorders 2011 Jun;131(1-3):379-87. PMCID: PMC3073153

Goldstein, JM, Cherkerzian, S, Seidman, LJ, Petryshen, TL, Fitzmaurice, G, Tsuang, MT, Buka, SL. Sex-Specific Rates of Transmission of Psychosis in The New England High-Risk Family. Schizophr Res. 2011 May; 128 (1-3):150-5. PMCID: PMC3085650

Goldstein JM, Cherkerzian S, Buka S, Fitzmaurice G, Susser E, Hornig M, Gillman M, Factor-Litvak P, Sloan RP.  Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later. Journal of Developmental Origins of Health and Disease 2011; 2 (6): 353–364. PMCID: PMC3558934

Abbs B, Liang L, Makris N, Tsuang M, Seidman LJ, Goldstein JM. Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical. NeuroImage 2011; 56(4):1865-74. PMCID: PMC3113542

Holsen LM, Savage CR, Martin LE, Bruce AS, Lepping RJ, Ko E, Brooks WM, Butler MG, Zarcone JR, Goldstein JM. Importance of Reward and Prefrontal Circuitry in Hunger and Satiety: Prader-Willi Syndrome vs. Simple Obesity. International Journal of Obesity 2011, October 25. PMCID: PMC3270121